SiM20 Posters

11 Sensors in Medicine 2020 Results Evalua�on of matrix effect on assay performance No significant matrix effect is observed with •untreated serum samples •whole blood at dilu�on factor 25% On-chip piperacillin calibra�on in 10% whole blood •Limit of detec�on 0.058 μM •Inter-assay coefficient is less than 12% Future work ß-lactam an�bio�cs 35 pigs Electrochemical microfluidic chip PK/PD insights for 3 an�bio�cs Correla�ons between blood-noninvasive matrices Benchmarking with a “gold standard” Whole blood Plasma Urine Breath Saliva Acknowledgement Authors would like to thank the German Research Founda�on (DFG) for funding this work under grant number DI 2345/3-1. 1. Ates H.C , Roberts J.A, Lipman J., Cass A.E.G., Urban G.A., Dincer C., On-Site Therapeutic Drug Monitoring, Trends in Biotechnology,2020, ISSN 0167-7799, https://doi.org/10.1016/j.tibtech.2020.03.001. 2. Bruch R, Kling A, Urban GA, Dincer C. Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation. J Vis Exp. 2017;(127):56105. Published 2017 Sep 19. doi:10.3791/56105 References H. Ceren Ates, M.Sc. IMTEK ‒ University of Freiburg Laboratory for Sensors Georges-Köhler-Allee 103 79110 Freiburg, Germany