SiM20 Posters

Sensors in Medicine 2020 20 ELECTROCHEMICAL OLIGONUCLEOTIDE TEMPLATED REACTIONS Robert B. Channon 1 , Philip Gillespie 1 , Md Nazmul Islam 2 , Xiaotong Meng 1 , Yu-Chih Chen 1 , Danny O'Hare 1 , Sylvain Ladame 1 1 Imperial College London, UK, 2 Teeside University, UK Potential vs Ag/AgCl / V Current / µA 1 st SCAN 2 nd SCAN Target nucleic acid acts as a template to capture two probe-modified peptide nucleic acids (PNA-aniline and PNA- catechol). Reaction of the probe heads generates an adduct that we can electrochemically detect. Electrochemical characterization of the two probe heads aniline (PNA-A) and catechol (PNA-C). 1 st cyclic voltammetry sweep (black line) triggers reaction and second scan show adduct oxidation peak at -0.1 V (red line)