SiM20 Posters

Sensors in Medicine 2020 26 Tunnel Magnetoresistance Sensor for Point-of-Care and Rapid Label-free Malaria Diagnosis Yuchen Li, Siming Zuo, Vahid Nabaei, Jacob Thompson, Nosrat Mirzai, Lisa Ranford-Cartwright , Hadi Heidari Microelectronics Lab (meLAB), James Watt School of Engineering, University of Glasgow, UK Institute of Biodiversity Animal Health & Comparative Medicine, University of Glasgow, UK hadi.Heidari@glasgow.ac.uk I NTRODUCTION To meet the demand for malaria diagnosis in malaria-endemic countries with low- resource, we need to design a cost-effective, easy-to-use, high-sensitivity and rapid diagnostic platform. However, all current diagnostics have their drawbacks, as is shown in Table.1, none of the existing malaria diagnostics can achieve rapid label- free diagnosis with high-sensitivity. Magnetic immunoassay is regarded as the most promising malaria diagnosis because hemozoin shows a paramagnetic property. Our objective is to use the tunnel magnetoresistance (TMR) sensor to detect the hemozoin and achieve a rapid label-free diagnosis with high sensitivity. Technique Sensitivity (Parasites/μL) Operation Time Operation Cost Operation Complexity Microscopy 50-500 60 min $5000 for a microscope $0.12–$0.40 for a test Experts RDT 100 15- 30 min $0.55–$1.50 Easy-to-use PCR 2-5 24 h $100 for a PCR thermal cycler $3.3 for a test Experts MOT 50-100 1 min 25 euro cents Easy-to-use MRR < 10 24 hours < $0.55 cents Expert Table 1 : Comparison table among malaria diagnostics. M ETHODOLOGY Figure 1 : (A) Paramagnetism of hemozoin particles; (B) The relationship between the sensor resistance and the direction of the hemozoin. Figure 2 : Schematic diagram of the margination device. (a) blood sample infected by malaria; (b) blood sample placed on the TMR sensor container; infected red blood cells (iRBC), healthy red blood cells (hRBC) and the external parallel magnetic field exerted by the Halbach cylinder; (c) TMR sensor to detect in-plane magnetic field produced by iRBC, linearization region is suitable for the design in this device (d) analogue-front-end circuit; (e) displaying obtained voltage signal using LABVIEW interface (f) Halbach cylinder composed of 8 arc-shape permanent magnets to produce maximum and minimum perpendicular magnetic field. M AGNETIC - ASSISTED M ALARIA D ETECTION P ROCESS www.melabresearch.com University of Glasgow, charity number SC004401