SiM20 Posters

Sensors in Medicine 2020 30 Developing an Electrochemical Glucose Sensor using Nanoband Electrodes F. Moore 1 , C. Dunare 1 , I. Schmueser 2 , A.R. Mount 2 , J.G. Terry 1 1 School of Engineering, 2 School of Chemistry, The University of Edinburgh Fiona.Moore@ed.ac.uk Detecting Glucose with Miniaturised Sensors Measuring glucose is essential for managing diabetes . Developing miniaturised electrodes is key for wearable and implantable biosensor systems. Minimal analyte depletion is advantageous for measuring in low concentrations and low sample volumes such as sweat . Nanoband Electrode • Arrays of 20 μm diameter • Functionalised with a mixture of GOx, BSA and glutaraldehyde Top Insulator Bottom Insulator Substrate Electrode 50 nm Enzyme Film Nanoband Diffusion • Higher sensitivity • Lower limit of detection • Deplete analytes less Linear vs radial diffusion Gluconolactone O 2 H 2 O 2 Glucose 2e - 2H + + O 2 Electrode Glucose Electrochemistry 0.5 V Glucose oxidase enzyme (GOx)