SiM20 Posters

37 Sensors in Medicine 2020 Result: Conclusion: Special thanks to Florian Blaser for his work on the paper-based lactate sensor and Vanessa Tomanek for assisting with the graphics Acknowledgement: 1 Rongen, et al. J. Pharm. Biomed. Anal., 1994, 12 (4), 433–462. 2 Ando et al. Photochem. Photobiol, 2007, 83 (5), 1205–1210. References: CL enhancement of m -carboxy luminol outperforms luminol in terms of sensitivity in all applied assay schemes. This signal enhancement led to higher resolution and lower LODs in real bioanalytical approaches. Application in paper-based microfluidics showed again CL enhancement with increased resolution for L-lactate detection. Quantification of the luminophore, using m -carboxy luminol provided up to 5-times lower limits of detection (LOD). Changing the assay strategies towards quantifying the metabolite H 2 O 2 , the sensitivity was increased up to 15-fold. This could be directly translated into a bioassay in which L-lactate was detected in artificial sweat based on lactate oxidase recognition resulting in an over 6-fold increased sensitivity. When applied to a competitive ELISA for diclofenac, higher resolution and almost two orders of magnitude lower LOD as for the colorimetric approach were obtained (3 pg mL -1 vs. 200 pg mL -1 ). Similarly, higher resolution was obtained when detecting L-lactate in a paper- based format.